Erratum to: Mechano-signaling in heart failure
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چکیده
منابع مشابه
ROS Signaling : Rapid Mechano - Chemo Transduction in Heart
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We report that in heart cells, physiologic stretch rapidly activates reduced-form nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) to produce reactive oxygen species (ROS) in a process dependent on microtubules (X-ROS signaling). ROS production occurs in the sarcolemmal and t-tubule membranes where NOX2 is located and sensitizes nearby ryanodine receptors (RyRs) in the sarco...
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Galectin-3 is a member of the galectin family, which consists of animal lectins that bind beta-galactosides. Recently, a role for galectin-3 in the pathophysiology of heart failure has been suggested. It was observed that galectin-3 is specifically upregulated in decompensated heart failure compared with compensated heart failure in animal models of heart failure. This has been associated with ...
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Heart failure is associated with generalized insulin resistance. Moreover, insulin-resistant states such as type 2 diabetes mellitus and obesity increases the risk of heart failure even after adjusting for traditional risk factors. Insulin resistance or type 2 diabetes mellitus alters the systemic and neurohumoral milieu, leading to changes in metabolism and signaling pathways in the heart that...
متن کاملMechano-Electric Feedback in the Fish Heart
BACKGROUND Mechanoelectric feedback (MEF) describes the modulation of electrical activity by mechanical activity. This may occur via the activation of mechanosensitive ion channels (MSCs). MEF has not previously been investigated in fish ventricular tissue even though fish can greatly increase ventricular end diastolic volume during exercise which should therefore provide a powerful mechanical ...
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ژورنال
عنوان ژورنال: Pflügers Archiv - European Journal of Physiology
سال: 2014
ISSN: 0031-6768,1432-2013
DOI: 10.1007/s00424-014-1562-7